Imbalance in oxidant/antioxidant system in different brain regions of rat after the infection of Japanese encephalitis virus

Abstract The imbalance in redox equilibrium is associated with several viral diseases however its role in Japanese encephalitis (JE) has not been reported. In the present study, we report the status of oxidant/antioxidant system in different brain regions in rat model of JE. Twelve days old Wistar strain rats were inoculated intracerebrally with a dose of 3 × 10 6  pfu of JE virus (JEV). The activity of manganese superoxide dismutase (Mn-SOD), catalase (CAT), glutathione peroxidase (GPx) and the levels of reduced glutathione (GSH) and malonaldialdehyde (MDA) were estimated in corpus striatum, frontal cortex, thalamus and midbrain on 0, 10 and 20 days post-inoculation (dpi). A significant increase in MDA levels in striatum ( p p p p p p p p