Biological studies of new organotin(IV) complexes of thioamide ligands.

Abstract New organotin(IV) complexes with heterocyclic thioamides 2-mercapto-benzothiazole (Hmbzt), 5-chloro-2-mercapto-benzothiazole (Hcmbzt) and 2-mercapto-benzoxazole (Hmbzo) of formulae [(C 6 H 5 ) 3 Sn(mbzt)] ( 1 ), [(C 6 H 5 ) 3 Sn(cmbzt)] ( 3 ) and [(C 6 H 5 ) 2 Sn(cmbzt) 2 ] ( 4 ), together with the already known [(C 6 H 5 ) 3 Sn(mbzo)] ( 2 ), [( n -C 4 H 9 ) 2 Sn(cmbzt) 2 ] ( 5 ) and [(CH 3 ) 2 Sn(cmbzt) 2 ] ( 6 ) were used to study their influence on the peroxidation of oleic acid. The influence of complexes ( 3 )–( 6 ) upon peroxidation of oleic acid showed that the formation of reactive radicals caused the initiation of the chain radical oxidation of the substrate. The influence of complexes ( 1 )–( 6 ) upon the catalytic peroxidation of linoleic acid by the enzyme lipoxygenase (LOX) was also studied and compared to those of cisplatin. Compounds ( 1 )–( 6 ) were finally tested for in vitro cytotoxicity against leiomyosarcoma cells.