The gaba system as a factor compensating the disturbed cerebral hemodynamics

Changes in the system of conversion of γ-aminobutyric acid (GABA) in ischemia and during specific inhibition of GABA-transaminase under conditions of quantitative measurement of the blood flow by the hydrogen clearance method revealed definite correlation between elevation of the GABA level in the brain and tissues of the cerebral arterial walls and the onset of compensation of the disturbed cerebral hemodynamics. Consequently, one of the principal manifestations of the increased quantity of endogenous GABA during insufficiency of the cerebral blood supply is its ability to improve the cerebral hemodynamics.