2-(3-benzyl-2-(dimethylamino) phenyl)acetamide, synthesis method and application thereof

2016 
The invention relates to a novel compound 2-(3-benzyl-2-(dimethylamino) phenyl)acetamide as well as a synthesis method and an application thereof. The structural formula of the compound is shown in the specification. The synthesis method comprises the following steps: adding 2-amino-3-benzoyl phenylacetamide into a reactor, adding an organic solvent and a methylation reagent, carrying out temperature control reflux reaction, performing filtering and decompress concentrating to obtain 2-(3-benzyl-2-(dimethylamino)phenyl)acetamide. The invention also provides the application of the compound 2-(3-benzyl-2-(dimethylamino)phenyl)acetamide as an impurity reference substance in the stability quality control of parapafine. The synthesis process is stable, simple to operate, high in purity and free of special harsh reaction conditions, and is an economical method for preparing 2-(3-benzyl-2-(dimethylamino)phenyl) acetamide;
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