EFFICIENCY OF ANTIOXIDANTS IN INTEGRATED THERAPY OF ACUTE ODONTOGENIC OSTEOMYELITIS IN CHILDREN

This paper presents the comparative generalization of the results obtained by studying the activation of the processes of lipid peroxidation and the state of antioxidant protection factors in the peripheral blood and unstimulated oral fluid fraction in patients having a complicated course of odontogenic mandibular osteomyelitis. To determine the effectiveness of natural antioxidants, which were additionally included in the therapy protocol for patients with this the disease, we created two similar groups of participants (22 and 23 people in each) aged 7 to 15 years. Based on our previous reports, on admission to the hospital, these patients demonstrated the activation of the lipid peroxidation processes and the reduction of antioxidant protection factors in biological substrates. The scope of the treatment measures described in the protocol did not allow us to normalize their components for the time of clinical recovery. This prompted us to prescribe tocopherol acetate and ascorbic acid as components of the integrated complex therapeutic measures. This helped to stabilize the levels of all indicators up to the time of clinical recovery in this group of patients and supported the feasibility of these pharmaceuticals as important components in the therapy of odontogenic inflammatory diseases.