Midlobular zone 2 hepatocytes: A gatekeeper of liver homeostasis.

The liver consists of different zones that vary in function depending on their lobular localization. It remained unclear which zone serves as a source of repopulating/regenerating hepatocytes; however, experiments by Wei et al. (2021) in 11 CreER knockin murine strains revealed a vital role for zone 2 hepatocytes in liver homeostasis.