Deslorelin treatment of hyperoestrogenism in neutered ferrets (Mustela putorius furo): a case report.

Hyperoestrogenism causing progressive alopecia in neutered ferrets may be induced by ovarian remnant syndrome (ORS) and nodular hyperplasia of the adrenocortex (hyperadrenocorticism, NHA). The objec - tive of the study was to determine whether a slow-release implant of a gonadotropin releasing hormone (GnRH) analogue, deslorelin, has any value in therapy of hyperoestrogenism of adrenocortical origin (NHA). Three sup- posed cases of NHA with alopecia and other clinical signs of hyperoestrogenism (n = 2 spayed females in oestrous and n = 1 castrated male) were treated with a subcutaneous implant of 4.7 mg deslorelin acetate. Blood samples were collected, and plasma levels of estradiol (E 2 ) were determined just before, and some weeks after treatment. For realistic monitoring, blood samples for E 2 determination were also taken from intact, healthy (untreated control) females after the beginning of heat (n = 5), or 9-21 days after, with hCG induced ovulation (n = 6), or