A method of manufacturing a patch, patch and package

Disclosed is a method for producing an adhesive patch using ropinirole as a drug, b Pini is contained in the adhesive layer in the roll free form in a supersaturated concentration and soluble type, harsh conditions without storage facility, such as a post-earthquake a even long it is stored in, and to provide a method for producing high levels and achievable patch both skin permeability and physical properties of the formulation. A A method of manufacturing a patch comprising a support layer and said support layer pressure-sensitive adhesive layer disposed on at least one surface of, A step A of the content in the pressure-sensitive adhesive layer to be obtained to obtain a pressure-sensitive adhesive layer composition contains an amount of B Pini roll free form to be from 5 to 13.2 wt%, Step B of heat 5 minutes to 24 hours at a temperature in the range of the pressure-sensitive adhesive layer composition 50 to 76 ° C., The pressure-sensitive adhesive layer composition after heating at an average temperature decrease rate of 1 to 20 ° C. / time and then cooled to room temperature, step C to obtain the adhesive layer containing a B Pini roll free form in a supersaturated concentration and soluble type, Production method of the adhesive patch, which comprises a. .BACKGROUND