Characterization of Adrenal Masses With Diffusion-Weighted Imaging

OBJECTIVE. The purpose of this article is to assess the role of diffusion-weighted MRI in characterizing adrenal masses. MATERIALS AND METHODS. A retrospective review of the MRI database from August 2007 to July 2009 was performed. The MRI examinations of 48 patients, with 49 lesions, were reviewed independently and blindly by two experienced abdominal radiologists who measured the signal intensities on in-phase and opposed-phase T1-weighted imaging and apparent diffusion coefficient (ADC). ADC measurements and quantitative parameters of chemical shift imaging (signal intensity index and adrenal-to-spleen ratio) were assessed separately and in combination. Lesions with indeterminate signal intensity index (< 16.5%) were considered benign if ADC was greater than or equal to 1.0 × 10–3 mm2/s and malignant if ADC was less than 1.0 × 10–3 mm2/s. Stepwise logistic regression analysis and receiver operating characteristic curves analysis were performed. RESULTS. There were 12 malignant and 37 benign lesions. On...