COMPARISON OF OXIDATIVE STRESS CONTENT DURING ON-PUMP AND OFF-PUMP CORONARY ARTERY BYPASS SURGERY

J Cardiovasc Thorac Res / 29 Original Article Comparison of Oxidative Stress Content During On-pump and Off-pump Coronary Artery Bypass Surgery Alireza Yaghoubi MD, Saeed Farzam MD, Masoud Pezeshkian MD, Zahra Golmohammadi MS Babak Nasiri MD, Rasoul Azarfarin MD, Mohammad Nouri MD, Naser Safaie MD, Azin Alizadeh Asl MD 1. Dept. of Cardiac Surgery, Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 2. Dept. of Cardiology, Dr Heshmat, Gilan University of Medical Sciences, Gilan, Iran. 3. Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 4. Dept. of Anesthesiology and Intensive Care, Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran . 5. Dept. of Clinical Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. 6. Dept. of Cardiology, Madani Heart Hospital, Tabriz University of Medical Sciences, Tabriz, Iran. (Received 30 Sep 2009; Accepted 9 Oct 2009) Background: In contrast to conventional on-pump coronary artery bypass grafting (CABG) surgery only mild increase of parameters of oxidative stress is reported during and after off-pump coronary artery bypass grafting. In this study, we attempted to determine the role of off-pump CABG in the myocardial and systemic inflammatory responses. Methods: One hundred patients who underwent elective CABG were divided to three groups: 1) patients underwent offpump CABG or 2) on-pump CABG surgery with controlled reperfusion and 3) on-pump CABG with noncontrolled reperfusion. We took patients systemic venous blood samples for the measurement of serum level malondialdehyde (MDA), TroponinC (cTnI) and total antioxidant (TAC) and blood level superoxiddismotas (SOD), before and after Ischemia and reperfusion. Results: Mean values of decrease left ventricular ejection fraction (LVEF) after surgery in patients group 3 were higher than patients group2 and also (LVEF) in patients group2were higher than patients group1(P<0.0001).There was significant difference in mean increase in CTnI levels among the three study groups (P <0.0001). The Serum concentration of MDA in the patients group3were significantly higher than other two groups (P <0.0001). The decrease SOD, TAC levels in patients patients group3were more than patients patients group2and than patients group1. Conclusion: We conclude that oxidative stress biomarker were increase in on-pump CABG. Controlled reperfusion onpump CABG in comparison with noncontroled reperfusion on-pump CABG reduces oxidative stress .We conclude that offpump CABG technique appears to reduce oxidative stress. J Cardiovasc Thorac Res 2009; Vol.1 (3): 29-34 *Corresponding Author: Alireza Yaghoubi MD, Department of Cardiac Surgery, Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Tel: 0411-3357770 Fax: 0411-3344021 E-mail: yaghoubia@tbzmed.ac.ir