Modified and immobilized preparations of basic polyvalent protease inhibitor for potential medical use

Several procedures for immobilization of basic polyvalent inhibitor of proteases on soluble and insoluble matrices of various chemical nature were studied. Water-soluble high molecular derivatives of the proteases inhibitor were produced, which exhibited the unaltered constants of trypsin inhibition, slower rate of elimination from circulation and the hepatotropism as compared with the native inhibitor. The higher therapeutic efficiency of the high molecular derivative of the proteases inhibitor and of the affinity sorbent, produced on its basis, as compared with the conventional methods of the experimental acute pancreatitis treatment, were confirmed by a number of biochemical data.