Eruca sativa Essential Oil Protects upon Hyperthyroidism Induced Damages in Rat

The study was conducted to evaluate the protective effects of Eruca sativa oil upon hyperthyroidism induced damages to thyroid, kidney and brain of male Wistar rats. Our experimental conditions revealed an obvious increase in the serum FT4, creatinine, urea and calcium levels together with significant decrease in TSH, proteins and uric acid. In addition, hyperthyroidism treatment triggered an oxidative stress in thyroid, brain and kidney as revealed by an increased level of lipid peroxidation, an increase of superoxide dismutase activity in kidney and brain and a decrease of glutathione peroxidase and catalase activities in thyroid, kidney and brain functions. When Eruca sativa oil was added, all this parameter was significantly shifted to more normal values. In conclusion, Eruca sativa oil displays beneficial effects upon thyroid dysfunction, nephrotoxicity, neurotoxicity and oxidative stress in hyperthyroidism treated animals. This property could be attributed to the presence of antioxidant components determined by GC-MS. The experimental protocol was performed according to the European convention for the protection of vertebrate animals used for experimental and other scientific purposes (Council of Europe No 123, Strasbourg) and approved by the ethics committee for research on laboratory animal use of our institution.