Distinct antigen receptor repertoires of two classes of murine epithelium-associated T cells

We demonstrate here that γ/δ TCRs of T cells in tissues are restricted in V gene usage with different elements predominating. The TCR junctional diversity of epidermal T cells, however, is extremely limited, whereas that of intestinal T cells is extremely diverse. The distinctive features of these two populations suggest that they develop or are selected differently for particular tissue-specific functions