Efficacy and safety of itraconazole in the treatment of deep fungal infections in severe burn patients

Objective To evaluate the efficacy and safety of itraconazole treating deep fungal infections in severe burn patients.Methods An open randomized trial was performed to access the cure rates of severe burn patients with deep fungal infections.A total of 23 burn patients who had proven or suspected deep fungal infections were enrolled in this study.Each patient was administered itraconazole(dosage:200 mg) at least 60 minutes twice in the first two days,then once a day in the following 3~14 days,followed by consecutive itraconazole(200 mg,Bid,p.o.) treatment for the next 4 weeks.Results Total clearance was about 60.87%,clinical efficacy was 86.96%,fungal clearance was 63.64%.Most patients experienced relief from clinical infectious symptoms,signs and systemical reactions.No adverse drug reaction occurred during this study.Conclusion Itraconazole was effective and safe in the treatment of deep fungal infections in severe burn patients.