Novel inflammatory markers associated with cognitive performance: Singapore Longitudinal Ageing Studies

Abstract We identified and validated several novel inflammatory markers of cognitive performance in community-living older persons. An exploratory study (n = 83) correlated 177 inflammatory markers assayed by Luminex with the Mini–Mental State Examination (MMSE) and identified 8 inflammatory markers for enzyme-linked immunosorbent assay (ELISA) and correlations with MMSE, Montreal Cognitive Assessment (MoCA), and cognitive impairment in the validation study (n = 139). The validation study replicated the significant associations of soluble interleukin-2 receptor alpha chain (sIL-2Rα; p  = 0.050), soluble tumor necrosis factor receptor 2 (sTNFR2; p  = 0.002) and soluble glycoprotein 130 (sgp130; p  = 0.026) with MMSE, and sIL-2Rα ( p  = 0.019) and sgp130 ( p