Morphofunctional changes in animal skin during combined administration of zinc sulfate and vitamin A

Morphological and histochemical skin properties were studied in male rats in single and successive peroral injections of Zinc sulphate and vitamin A. Long term (25 d) peroral administration of vitamin A 2 mg/100 g in dose was shown to cause hypozincaemia. Zinc sulphate and vitamin A are capable of influencing proliferation and protein metabolism of epidermal cells and number of lymphocytes and mast cells in dermis. With the aim of the drugs named thickness of epidermis, ratio of its layers thickness as well as the rate of protein synthesis in germinal layer of epidermis can be changed purposefully. These parameters depend both on the drug injection technique (single, separated or successive injections) and time periods. Perspective of obtaining a complexed biocoordinative compound on the base of vitamin A and microtrace element of Zinc is discussed.