Effects of Dietary Nutrients on Intestinal Taurocholic Acid Absorption

AbstractIn order to assess the intraluminal event that may be responsible for bile acid malabsorption in cystic fibrosis, taurocholic acid absorption was determined in the presence and absence of representative unhydrolyzed dietary nutrients in animal models. Triglyceride (corn oil) significantly reduced taurocholic acid uptake by villi isolated from hamster ileum. Likewise, when combinations of nutrients were studied, only those combinations of nutrients containing triglyceride inhibited taurocholic acid absorption. Neither starch nor albumin or a combination of these two substrates altered this process. Triglyceride also produced significant reductions in taurocholic acid absorption in perfused segments of terminal ileum of rats as determined by reduced biliary recovery of absorbed bile acid. Again, starch and albumin had no effect in vivo. These findings support an “intraluminal theory” of bile acid malabsorption in cystic fibrosis limited to only the adverse influence of unhydrolyzed lipid on this nor...