Preparation method and use of 3,3'-methylenebis(1H-Indole)

The invention provides a preparation method of 3,3'-methylenebis(1H-Indole). The preparation method comprises the following steps that 1, indole and p-toluenesulfonic acid are dissolved in a solvent comprising water and 95wt% of ethanol and a formaldehyde aqueous solution is added into the mixed solution in a nitrogen protective atmosphere; 2, the mixture obtained by the step 1 undergoes a reaction at a room temperature in dark for 20 to 30 hours, preferably, for 24 hours; 3, reaction products are filtered so that solids precipitated by the step 2 are obtained; and 4, the solids obtained by the step 3 are subjected to recrystallization purification. In addition, the invention also provides a use of the prepared 3,3'-methylenebis(1H-Indole) which is a high purity compound in preparation of drugs.