Mitoxantrone in advanced renal cancer: A phase II study in previously untreated patients from the EORTC Genito-Urinary Tract Cancer Cooperative Group

Abstract Mitoxantrone at a dose of 15 mg/m 2 i.v. q 3 weeks failed to produce responses in 29 adequately treated patients with measurable advanced renal cell carcinoma. The side-effcts observed in this group of patients with a good performance status were generally mild. On the basis of this negative result, the application of mitoxantrone in this disease is not recommended.