Effects of Aerobic Exercise Intensity Difference on GLUT-1, 3 and GLP-1R mRNA Expression of Brain Tissue in Type 2 Diabetes Rats

This study was to investigate the effects of aerobic exercise intensity difference on GLUT-1, 3 and GLP-1R mRNA expression of brain tissue in type 2 diabetes rats. At 7 weeks of age, OLETF rats(N=40) were randomly assigned to : diabetic control group(DM, n=10), DM+low intensity exercise group(DM+LEX, n=10), DM+moderate intensity exercise group(DM+HEX, n=10), and DM+high intensity exercise group(DM+HXE, n=10). The exercise training group performed a treadmill running(60 min, 3 times/week) for 12 weeks. Compared with the DM group, the escape latency were significantly decreased in all exercise groups(p<.05). In the brain, GLUT-3 and GLP-1R mRNA were significantly increased in all exercise groups compared to DM, but GLUT-1 was no significant. These results suggest that aerobic exercise training contributes to improvements brain glucose metabolism by increasing glucose transporter, which may prevent the development of T2DM-related cognitive dysfunction.