Beneficial Effects of Cerebellar Low Frequency Repetitive Transcranial Magnetic Stimulation on the Patient with Meige's syndrome

Meige's syndrome, one type of the segmental cranial dystonia, is characterized by blepharospasm and oromandibular dystonia and can be involved with involuntary movement of lower facial muscles, mouth, pharyngeal or cervical muscles. The exact pathophysiology is still obscure. Clinically, there are no curative drugs and the therapeutic effects of botulinum toxin injection is limited. Repetitive transcranial magnetic stimulation (rTMS), one of the noninvasive techniques of brain stimulation, can be able to induce lasting changes of cortical excitability and remodeling of brain networks. In this study, we first reported the beneficial and long-lasting effect of cerebellar low-frequency rTMS on the patient with Meige's syndrome, which seems to offer the alternative therapeutic method for the disease.