Susceptibility profile of Candida spp. isolated from humans and dogs with stomatitis to the essential oil of Thymus vulgaris
2013
Candida spp. form a part of human and animal oral cavity flora. However
Candida spp. is the main cause of dental related stomatitis in humans and
stomatitis in dogs. Stomatitis treatment implies the use of azoles and
polyenes to which yeasts build up resistance. The research is directed to the
use of natural compounds such as essential oils. The aim of this paper is to
define the antifungal activity of thyme oil on 15 clinical strains of Candida
spp., isolated from humans and dogs and to determine if there is a difference
in susceptibility between human and dog isolates. Sampling in patients with
stomatitis was done by swabbing the denture or oral mucosa swab while
sampling in dogs was done by swabbing the oral cavity mucosa after stomatitis
has been diagnosed. In order to investigate the antifungal activity of thyme
oil in vitro, microdilution method was used. Thyme oil expressed antifungal
effects on all investigated strains. Also, our data show that the values of
minimum fungicide concentration (MFC) and minimum inhibitory concentration
(MIC) are lower in human strains. Explanation is that in most cases,
stomatitis in humans is asymptomatic and thus not treated, so Candida strains
have not developed resistance. On the other hand, stomatitis in dogs is
followed by a marked clinical picture and treated is by antimicotics (mostly
by azoles), therefore resistant Candida strains are more likely to occur.
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