Linaclotide Improves Gastrointestinal Transit in Cystic Fibrosis Mice by Inhibiting Sodium/Hydrogen Exchanger 3

Daniel R. McHugh,Calvin U. Cotton,Fraser J. Moss,Megan Vitko,Dana M. Valerio,Thomas J. Kelley,Shuyu Hao,Anjum Jafri,Mitchell L. Drumm,Walter F. Boron,Robert C. Stern,Kimberly McBennett,Craig A. Hodges

Linaclotide Improves Gastrointestinal Transit in Cystic Fibrosis Mice by Inhibiting Sodium/Hydrogen Exchanger 3

2018

Daniel R. McHugh
Calvin U. Cotton
Fraser J. Moss
Megan Vitko
Dana M. Valerio
Thomas J. Kelley
Shuyu Hao
Anjum Jafri
Mitchell L. Drumm
Walter F. Boron
Robert C. Stern
Kimberly McBennett
Craig A. Hodges

Linaclotide’s primary mechanism of action in alleviating chronic constipation is through cystic fibrosis transmembrane conductance regulator (CFTR), negating its use in patients with cystic fibrosi...

Keywords:

Cystic fibrosis
Diabetes mellitus
Sodium–hydrogen antiporter
Constipation
Cystic fibrosis transmembrane conductance regulator
Biochemistry
Biology
Pharmacology
Mechanism of action
Linaclotide
Gastrointestinal transit
chronic constipation
Internal medicine
Gastroenterology

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