AQUEOUS SOLUTIONS OF POLY-N-ALKYL-SUBSTITUTED ACRYLAMIDES : STRUCTURE AND PROPERTIES RELATED TO TARGETED TRANSPORT

Temperature dependence of structure and properties of poly- N-alkyl-substituted acrylainides and their aqueous solutions has been studied by IR-Fourier spectroscopy technique. For poly-N-alkyl- substituted acrylamides showing lower critical solution temperature, a specific H-bonded ring structure involving alkyl amide units of a polymer and hydroxyl functions of water was discovered. A new approach to the targeted transport of physiologically active compounds was proposed. The approach involves the immobilization of these compounds on activated poly-N-alkylsubstituted acrylamides and heating the delivery site above critical temperature. It is known that the solubility of a polymer in a solvent is determined by the balance