Centromeric Plasmids and Artificial Chromosomes: New Kids on the Plasmodium Transfection Block

capping(Chiu et al., 2002), and it will be inter-esting to determine whether Set7/9-KMT7 and the lysine 51 methylation ofTat plays a role in capping. The Tat/P-TEFb complex also associates withthe splicing factor SKIP during RNAP IIelongation, and this contributes to Tattransactivation and influences alternativesplicing (Bre`s et al., 2005). It seems likelythat covalent modifications of Tat caninfluence these aspects of Tat function.For cellular mRNAs, RNAP II elongationis also coupled to 3