Prolidase deficiency: a new genetic cause of combined pulmonary fibrosis and emphysema syndrome in the adult

Pulmonary fibrosis is considered to result from recurrent alveolar epithelial injury coupled with dysfunctional alveolar wound healing mechanisms, some of which have a genetic background. Pulmonary fibrosis in the adult has not been previously associated with prolidase deficiency, an innate deficiency of aminoacids metabolism. Footnotes This manuscript has recently been accepted for publication in the European Respiratory Journal . It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article. Conflict of interest: Dr Cottin has nothing to disclose. Conflict of interest: Dr Nasser has nothing to disclose. Conflict of interest: Dr Traclet has nothing to disclose. Conflict of interest: Dr Chalabreysse has nothing to disclose. Conflict of interest: Dr Lebre has nothing to disclose. Conflict of interest: Dr Si-Mohamed has nothing to disclose. Conflict of interest: Dr Philit has nothing to disclose. Conflict of interest: Dr Thivolet-Bejui has nothing to disclose.