Association of IL-1B gene polymorphism and H.pylori infection with gastric cancer in Chinese patients with Han nationality

Objective:The H.pylori infection rate of and IL-1B gene polymorphism in gastric cancer patients and normal people were investigated.The effect of IL-1B gene polymorphism on the development of gastric cancer inducing the H.pylori infection.Methods:IL-1B polymorphisms were analyzed with PCR-RFLP in 84 cases of gastric cancer and 84 cases of normal people in low-prevalence region. The H.pylori infection rates were examined with ELISA.Results:T/T carrier frequencies of IL-1B-511 was remarkably higher in gastric cancer patients compared with the normal people(P0.05); T/T carrier frequencies of IL-1B-31 was similar in all of the population. H.pylori infection rate of 84 cases gastric cancer patients was remarkably higher than normal people(P0.01). T/T carrier frequencies of IL-1B-511 was remarkably higher in gastric cancer patients H.pylori infected compared with the normal people.Conclusion:IL-1B-511 T/T genotype might be increase the risk of gastric cancer infected by H.pylori in Chinese population. IL-1B-31 genotype do not increases the risk of gastric cancer infected by H.pylori.