CA2+-INDUCED ERYTHROCYTE HYPERPOLARIZATION IN PATIENTS WITH TUMORS OF DIFFERENT LOCALIZATION

In patients with lung cancer and malignant tumors of the head and neck, erythrocyte hyperpolarization associated with the opening of Ca2+-activated potassium channels develops with lower rate and amplitude compared with that in healthy donors. Restoration of normal membrane potential is Ca2+-ATPase-dependent. The rate of restoration is significantly higher in patients with tumors. Two groups with different hyperpolarization response and their dynamics during chemotherapy were identified in patients with lung cancer. Ca2+-induced erythrocyte hyperpolarization and its dynamics during cytostatic therapy depend on tumor localization and histological type.