Distribution of pathogenic bacteria and the use of antibiotics in complicated urinary tract infection

OBJECTIVE To analyze the distribution of the common pathogenic bacteria and the use of antibiotics in complicated urinary tract infection for clinical reference of rational use of antimicrobial agents.METHODS The medical records of patients hospitalized in the dept.of urinary surgery in our hospital from Jan 2009 to Dec antimicrobial agents 2010 were retrospectively collected for analyses of the results of mid-stream urine culture and antibiotic resistance,meanwhile,the current utilization of antimicrobial agents in the dept.of urinary surgery was analyzed.RESULTS 156 strains complicated urinary tract infection pathogens were isolated including 69.9% Gram-negative bacteria,24.3% Gram-positive bacteria,5.8% fungi.Escherichia coli were the most common among Gram-negative bacteria,accounting for 40.4%.Results from the sensitivity test comfirmed that Escherichia coli were the least resistant to imipenem,meropenem,followed by amikacin,cefoperazone/sulbactam.ESBLs-producing Escherichia coli,Klebsiella pneumoniae detection rates were 23.80%,38.4%.Gram-positive bacteria were sensitive to linezolid,vancomycin,teicoplanin.β-lactam antibiotics antimicrobial drug use accounted for the top.CONCLUSION The antibiotics should be used rationally according to the result of susceptibility test in treating patients with complicated urinary tract infection.