Histomorfometria tegumentar de ratas wistar ooforectomizadas
2018
The skin is the largest organ in the body, which makes it a chronological factor of our age.
And among the hormones that influence the integument we have the estrogen, which
unleashes several effects on it, as the reduction of its elasticity due to the case of low levels of
hormones.As to the bilateral oophorectomy, it causes an abrupt reduction of serum estrogen
levels and is used as a surgical model for menopause induction. Thus, the study aimed to
analyze the micro anatomical components of the skin of oophorectomized rats. 19 adult
female rats, Wistar lineage, were used, weighing about 300g, coming from the UFPE
vivarium.This study was a case-control one, and the animals were divided into two groups.
The results showed that Group I presented a greater total thickness of the skin, an increased
thickness of the layers of the epidermis and a higher percentage of fibroblasts and collagen
fibers in relation to group II, thus it is concluded that both groups presented all cells of
tegumentary lineage, however the group II presented a smaller thickness of the skin, layers of
the epidermis and percentage of collagen fibers and fibroblasts, implying that, in addition to
estrogen, other hormones also can exert influence on the integument.
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