Synthesis and In Vitro Anti-Breast Cancer Activity of Trametenolic Acid B Derivatives
2013
Six compounds were synthesized from the lanostane-type tetracyclic triterpenoid of trametenolic acid B with the aim of obtaining more active compounds, which were characterized by NMR, IR, ESI-MS and elemental analysis. Their cytotoxic activities were evaluated against the breast cancer cell line MD-AMB-231. The compound 3b exhibited the best anti-proliferative effect than trametenolic acid B and other derivatives with the IC50 of 17.78 µM.
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