Meta analysis on the immunogenicity of domestic influenza virus vaccines

Objective To evaluate the immunogenicity of domestic influenza virus vaccines.Methods The published studies that compared the immunogenicity between domestic and imported influenza virus vaccines in Chinese population before September 2012 were collected and evaluated with meta analysis using Stata 10.0 software package.Results A total of 20 studies that met inclusion criteria were included in this review.The meta analysis result showed that the positive seroconversion rate of B flu virus strain of domestic influenza virus vaccines was significantly higher than that of imported influenza virus vaccines(P=0.036,RR = 1.036,95%CI:1.002- 1.070).No significant difference in three strains' protective rate, H1N1 and H3N2 positive seroconversion rate was found between the domestic and imported influenza virus vaccines(P 0.05).Stratified analysis showed that domestic whole influenza virus vaccine had significantly higher protective rate(P = 0.031,RR = 1.059,95%CI:1.005-1.116),positive seroconversion rate(P=0.024,RR= 1.040,95%CI:1.005-1.077) of B flu virus strain,and protective rate of H3N2 flu virus strain(P=0.019,RR= 1.053,95%CI:1.009-1.098) than imported influenza virus vaccines.Conclusion Domestic influenza virus vaccines have desirable immunogenicity.