Cerebrospinal fluid oxytocin concentration in schizophrenic patients does not differ from control subjects and is not changed by neuroleptic medication

Abstract Cerebrospinal fluid (CSF) oxytocin concentrations in 20 neuroleptic-treated schizophrenic patients, 31 neuroleptic-withdrawn schizophrenic patients, and 15 normal control subjects were compared. Neither within-subject comparisons of CSF oxytocin concentration measurements made during neuroleptic treatment and withdrawal ( n = 11), nor comparison of the combined neuroleptic-withdrawn and neuroleptic- treated patient group ( n = 40) with control subjects ( n = 15) differed significantly, suggesting that CSF oxytocin concentration is not altered in schizophrenia.