A RANDOMISED, DOUBLE BLIND, PLACEBO CONTROLLED STUDY TO EVALUATE THE EFFECT OF ISOFLAVONES ON ADP AND EPINEPHRINE INDUCED PLATELET AGGREGATION IN OOPHORECTOMISED WOMEN

Summary The present study was conducted with an objective to probe into the cardiprotective mechanism of isoflavones by evaluating their platelet aggregation inhibitory potential in oophorectomised women in a randomised, double blind, parallel, placebo controlled manner. 43 women were randomised to receive 75mg/day isoflavones tablet or placebo for 12 weeks. ADP and epinephrine induced platelet aggregation was determined at baseline and at the end of study. Platelet aggregation was not significantly altered with ADP (student’s paired t test, P value for isoflavones: 0.19; for placebo: 0.70) or epinephrine (student’s paired t test, P value for isoflavones: 0.65; for placebo: 0.64) after 12 weeks in either of the drug or placebo groups. Also, the median change in platelet aggregation at the end of 12 weeks with study drug was not significantly different as compared to the placebo with either ADP (unpaired t test, P value: 0.27) or epinephrine (unpaired t test, P value: 0.52). There was no statistically significant difference in the proportion of patients experiencing adverse events in two groups (P value: 1.00).