Effects of Xuezhikang on blood levels of hs-CRP in patients with CHD after percutaneous coronary intervention

Aim:To investigate the effects of Xuezhikang on blood levels of high sensitive C-creative protein(hs-CRP) in patients with CHD after percutaneous coronary intervention(PCI).Methods:Seventy-three patients with chronic stable angina scheduled for PCI were enrolled in the study.Patients were consecutively assigned to Xuezhikang-treated group (n=35) or control group (n=39) before 7 days of the procedure.There were no difference between the two groups at age,sex and other clinical characteristics.In addition to conventional treatment for these two groups,the Xuezhikang group received oral Xuezhikang (1 200 mg/d, for 7 days);while patients in control group were given the same cure as the Xuezhikang group except Xuezhikang. Fasting venous blood of 3 mL were collected from each patient at baseline and every day after the procedure for five days. Serum hs-CRP levels were quantitative analysised, and compared statistically.Results:Detection of hs-CRP was significantly higher after the procedure compared with baseline in two groups. The extension lower in the Xuezhikang-treated compared with the placebo group.Conclusion: Pretreatment with Xuezhikang 1 200 mg/d for 7 days significantly reduce the increasing extension of hs-CRP levels in patients with CHD after PCI.