Treatment of duodenal ulcer with omeprazole or ranitidine in a Brazilian population: a multicenter double-blind, parallel group study.

Two hundred and forty-one patients with at least one ulcer at stage A1 or A2, measuring at least 5 mm in its larger diameter, were included in this Brazilian doubleblind randomized study. Patients received omeprazole 20 mg in the morning (n=120) or ranitidine 300 mg at night (n=121) for 2 wk; unhealed ulcers were treated for an additional 2 wk. At the end of 4 wk unhealed ulcers were treated openly with omeprazole 20 mg o.m. for 4 wk. Healing rates at 2 and 4 wk were 67.3% and 92.9% for omeprazole and 39.8% and 82.0% for ranitidine (per protocol analysis)