1126 High dose treatment with ice regimen followed by autologous hematopoietic rescue in cancer patients

Fourteen patients diagnosed with neoplastic disease (5 breast cancers, 9 lymphomas) were treated with Ifosphamide 12 g/sqm, Carboplatin 1500 mg/sqm and VP-16 1800 mg/sqm, followed by either PBSC (n = 9) or Bm (n = 5) rescue. In 8 PBSC infused pts, the cells were collected after a 4 days G-CSF course (15 mcg/kg), without any mobilization chemotherapy. The pts infused with BM received G-CSF (5 mcg/kg) starting on +6. All patients were able to complete the regimen: major toxicity was represented by vomiting and mucositis (grade 1–3); 7 required TPN. Transitory increase of hepatic enzymes was also observed. All pts achieved complete hematopoietic reconstitution, with an advantage of PBSC in platelets recovery. Median hospitalization time after the infusion was 14 days (range 11–22).