Biocompatible Smart Matrices Based on Poly (3,4-ethylenedioxythiophene)-Poly (N-isopropylacrylamide) Composite

The study investigated the use of composite of conducting poly(3,4-ethylenedioxythiophene) and temperature responsive poly(N-isopropylacrylamide) nanofibers as scaffold for tissue engineering application. The nanofibers of PNIPAm and PEDOT-PNIPAm composite were fabricated using electrospinning technique. FTIR was used to check the chemical structure of the composite while the conducting nature of the composite material was investigated by means of cyclic voltammetry. The average diameter of the PNIPAm and the composite nanofibers was investigated by using scanning electron microscopy, which indicates that the composite has some what more average diameter than the PNIPAm nanofibers alone. The biocompatibility of the material was studied by seeding L929 fibroblast cells on the nanofibers surface. It was seen that PEDOT-PNIPAm composite nanofibers shows highest cell growth and % live of around 98% indicating the use of these nanofibers as scaffold for the tissue engineering application.