Renin and Inactive Renin (Prorenin) in the Plasma of Patients with Malignant Renal Tumours
1987
Plasma active and inactive renin (prorenin) concentrations were measured in 26 adults with renal carcinoma and 8 children with nephroblastoma. In patients with carcinoma, plasma total renin concentration was slightly raised in 8 patients and markedly in one, in whom the increase was due to a more than 10-fold excess of inactive renin. Total renin concentration was raised in 7 out of 8 cases of nephroblastoma, the increase being due to excess inactive renin. It is likely that this represented oversecretion of a renin precursor, as inactive renin from the plasma of a patient with renal carcinoma showed similar biochemical characteristics to pure human prorenin.
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