Synthesis of nanoporous calcium carbonate spheres using double hydrophilic block copolymer poly(acrylic acid-b-N-isopropylacrylamide)

Abstract We report self-assembly of double hydrophilic block copolymer poly(acrylic acid- b - N -isopropylacrylamide) in aqueous solution. Self-assembly of calcium ions chelated complex micelles upon mineralization reaction forms calcium carbonate (CaCO 3 ) sphere. High porosity on CaCO 3 spheres can accommodate a large amount of anticancer drug (doxorubicin) and achieve sustainable drug release.