Oral absorption, metabolism and excretion of 1-phenoxy-2-propanol in rats

1. This study was designed to determine the absorption, metabolism and excretion of 1-phenoxy-2-propanol in Fischer 344 rats following oral administration in an effort to bridge data with other propylene glycol ethers.2. Rats were administered a single oral dose of 10 or 100 mg kg−1 14C-1-phenoxy-2-propanol as a suspension in 0.5% methyl cellulose ether in water (w/w). Urine was collected at 0–12, 12–24 and 24–48 h and faeces at 0–24 and 24–48 h post-dosing and the radioactivity was determined. Urine samples were pooled by time point and dose level and analysed for metabolites using LC/ESI/MS and LC/ESI/MS/MS.3. The administered doses were rapidly absorbed from the gastrointestinal tract and excreted. The major route of excretion was via the urine, accounting for 93 ± 5% of the low and 96 ± 3% of the high dose. Most of the urinary excretion of radioactivity occurred within 12 h after dosing; 85 ± 2% of the low and 90 ± 1% of the high dose. Total faecal excretion remained < 10%. Rats eliminated the entire ...