Comparison of direct assay and friedewald formula for determination of LDL cholesterol
2014
Cardiovascular diseases are a veritable public health problem worldwide. Its diagnosis and monitoring
require among other things the determination of serum LDL cholesterol levels. For this, two methods of
determination are often used: direct measurement and the Friedewald equation. The Friedewald formula
is commonly used especially where the reference method is unavailable for technical and financial
reasons. We investigated lipid status in one hundred subjects comparing the enzymatic method and
LDL cholesterol estimation using the Friedewald formula. The MultiQC 6.0 software and Studentâs test
were used to analyse the results and P < 0.05 was considered to be statistically significant. Correlation
with two methods was satisfactory with only a few discordant results. However, Friedewald equation
always keeps its usefulness in our resource limited countries.
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