Regulation of the phagocyte NADPH oxidase activation

The phagocyte NADPH oxidase is a multicomponent activatable enzyme comprising the major phagocyte antimicrobial systems.The oxidase system includes both membrane-bound and soluble cytosolic proteins.The primary feature of this enzyme is stimulus-dependent activation and which mechanism is the phosphorylation and translocation of a complex of cytosolic factors to the membrane,where they associate with a flavocytochrome enzyme.The fully assembled complex functions as an electron transport system,moving electrons from cytosolic NADPH to molecular oxygen to form superoxide anion(O2-),which,along with subsequent reactive products called respiratory burst,exerts microbicidal and cytotoxic activities.This activated process of NADPH oxidase is regulated by regulatory subunits,upstream mediators,and the other factors.