Effects of multivitamin, multimineral and phytonutrient supplementation on selected nutrient levels in blood and heart health risk factors in Russian population (831.4)

The primary objective of this exploratory study was to evaluate the effect of a multivitamin multimineral with phytonutrient supplement on heart health risk factors. One hundred twenty healthy adults (40-70 y) were recruited in this 8-week randomized double blind placebo control study. B-carotene, a-tocopherol, vitamin C, red blood cell (RBC) folate, B6, B12, Zn, Se content in blood were measured on Day 1, 28 and 56 and quercetin was measured on Day 1 and 56. Heart health risk factors such as homocysteine (Hcy), high-sensitivity C-reactive protein (hs-CRP), oxidized LDL (ox-LDL), gamma-glutamyl transferase (GGT), uric acid and blood lipid profile were monitored on Day 1 and 56. Results showed that supplementation significantly improved quercetin (p=0.0047), vitamin C (p=0.0011), RBC folate (p=0.0027) and B6 (p=0.0012) status after 8 weeks of consumption. A greater decrease of Hcy (p=0.0314), GGT (p=0.0545) and uric acid (p=0.1683) was also observed. However, a lesser degree of increase of hs-CRP (p=0.2511...