1-Formyl-7-hydroxy-6,7-dihydro-5H-pyrrolizine (1-CHO-DHP)-cysteine Conjugates - Metabolic Formation and Binding to Cellular DNA.

Xiaobo He,Qingsu Xia,Yuewei Zhao,Peter P. Fu

1-Formyl-7-hydroxy-6,7-dihydro-5H-pyrrolizine (1-CHO-DHP)-cysteine Conjugates - Metabolic Formation and Binding to Cellular DNA.

2020

Xiaobo He
Qingsu Xia
Yuewei Zhao
Peter P. Fu

1-Formyl-7-hydroxy-6,7-dihydro-5H-pyrrolizine (1-CHO-DHP) is a potential proximate carcinogenic metabolite of pyrrolizidine alkaloids. In the present study, we determined that reaction of 1-CHO-DHP...

Keywords:

Conjugate
Biochemistry
Chemistry
Cysteine
Pyrrolizidine
Metabolite
cellular dna
Carcinogen

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