SYNTHESIS OF HAPTENS FOR THE DEVELOPMENT OF A SOLID-PHASE IMMOBILIZED EPITOPE-IMMUNOASSAY (SPIE-IA) OF AZT-TP

Abstract The synthesis of the reduced form of AZT-triphosphate, 3′-amino-3′-deoxythymidine-5′-triphosphate, and of its stable analog, 3′-amino-3′-deoxythymidine-5′-(α,β:β,γ-bis-methylene)triphosphate, is described. AMT-TP and AMT-PCPCP were prepared to develop a specific immunometric assay for AZT-TP.