Abstract 20669: Structural Basis for the Antiarrhythmic Blockade of a Potassium Channel With a Small Molecule

Yoshio Takemoto,Diana P. Slough,Gretchen Meinke,Chris Katnik,Michelle Reiser,Chidipi Bujjibabou,Javier Cuevas,Andrew Bohm,Yu-shan Lin,Sami F. Noujaim

Abstract 20669: Structural Basis for the Antiarrhythmic Blockade of a Potassium Channel With a Small Molecule

2017

Yoshio Takemoto
Diana P. Slough
Gretchen Meinke
Chris Katnik
Michelle Reiser
Chidipi Bujjibabou
Javier Cuevas
Andrew Bohm
Yu-shan Lin
Sami F. Noujaim

Background: The acetylcholine activated inward rectifier potassium current (IKACh) is constitutively active in persistent atrial fibrillation (AF). We tested the hypothesis that blocking IKACh with...

Keywords:

Pharmacology
Potassium channel
Inward-rectifier potassium ion channel
Small molecule
Blockade
Atrial fibrillation
persistent atrial fibrillation
Medicine
Acetylcholine
constitutively active

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