Sinteza biološki aktivnih cikličkih derivata 5(6)-amino supstituiranih benzimidazola

This work presents the synthesis of novel 2-benzimidazolyil-substituted acrylonitrile 6 and it's cyclic analog, benzimidazo[1,2-ɑ]qinoline 7. Novel compounds were prepared by using a classical reactions of organic chemistry and microwave assisted amination. Benzimidazolyilsubstituted acrylonitrile 6 was prepared in reaction of 2-cyanomethyl-5(6)- piperidinylbenzimidazole 4 with o-chlorobenzaldehyde 5. Benzimidazo[1,2-ɑ]quinoline 7 was prepared by thermal cyclization of acrylonitrile 6 in sulfolane as a mixture of two regioisomers. The structures of all compounds were determined by means of 1H and 13C NMR and UV/Vis and fluorimetric spectroscopy.