Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia.
2012
a b s t r a c t Therapy-related acute promyelocytic leukemia (t-APL) has been reported as a late complication of expo- sure to radiotherapy and/or chemotherapeutic agents targeting DNA topoisomerase II. We have analyzed in t-APL novel gene mutations recently associated with myeloid disorders. Unlike previous reports in acute myeloid leukemia (AML), our results showed neither IDHs nor TET2 mutations in t-APL. However we found an R882H mutation in the DNMT3A gene in a patient with t-APL suggesting a possible role of this alteration in the pathogenesis of t-APL.
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