ALLOSTERIC MODULATION OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS

Bruno Buisson,Daniel Bertrand

ALLOSTERIC MODULATION OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS

1998

Bruno Buisson
Daniel Bertrand

Abstract The structure-function relationship of the neuronal nicotinic acetylcholine receptor is examined in the light of the allosteric concepts. Effects of site-directed mutagenesis as well as those caused by allosteric effector of the physiological and pharmacological receptor properties are discussed.

Keywords:

Acetylcholine receptor
Muscarinic acetylcholine receptor M5
Nicotinic agonist
Alpha-4 beta-2 nicotinic receptor
Muscarinic acetylcholine receptor
Nicotinic acetylcholine receptor
Allosteric regulation
Ganglion type nicotinic receptor
Endocrinology
Molecular biology
Internal medicine
Biology
Cell biology
Neuroscience

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